Evaluation of Antioxidant and Antitumor Activities of Wrightia arborea

Wrightia arborea (Br.) (Family-Apocynaceae), locally known as Sathkurchi, is a small deciduous tree with branches and densely velvety leaves. This study was designed to investigate the antioxidant anti tumor activities of leaves W. arborea.
 Antioxidant potential evaluated in vitro by DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging- reducing power- assay method which concentration dependent that 25-200 µg/ml. The extract showed scavenging activity IC50 value 15.23 ± 4.10 µg/ml for also dose manner. In addition, total phenol flavonoid content were determined Folin-Ciocalteu reagent found be 112.54 9.74 mg/g plant (in GAE) 247.14 15.45 quercetin equivalent), respectively. capacity phosphomolybdenum 117.27 12.36 ascorbic acid equivalents). effect methanol extractwas doses 5, 10 20 mg/kg b.wt against Ehrlich ascites carcinoma (EAC) mice respect determination volume, weight, % cell growth inhibition, increase life span (%ILS), hematological parameter (WBC, RBC hemoglobin).
 decreased weight significantly compared control group at all mentioned highest observed b. wt. (1.28 0.15 g). inhibition increased manner like 36.43 7.45, 58.76 9.43 98.43 12.45 10, b.wt. %ILS enhanced where maximum (105.5 3.57). Heamoglobin (Hb) 8.12 2.6, 10.23 1.62 12.12 2.09 g/dL respectively, EAC (4.95 1.80 There significant (p< 0.05, p< 0.01, p<0.001) decrease count WBC counts treated animals when animals.
 first report biological it well antitumor activity.